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Cortical regions accrued 1 to 2% deletion levels between
ages 80-90, and the putamen accrued up to 12% of this deletion after age 80. The
study presented evidence that HD patients have much higher mtDNA deletionlevels
than agematched controls in the frontal and temporal lobes of the cortex.
Temporal lobe mtDNA deletion levels were 11 fold higher in HD patients than in
controls, whereas the frontal lobe deletion levels were fivefold higher in HD
patients than in controls...
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There was no statistically significant difference in
the average mtDNA deletion levels between HD patients and controls in the
occipital lobe and the putamen. The increase in mtDNA deletion levels found in
HD frontal and temporal lobes suggests that HD patients have an increase mtDNA
somatic mutation rate...
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