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Science
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| Number of pages / Number of words: |
3 / 776 |
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This decrease in transporter efficacy is directly related to the mutations in genes KCNQ1 and KCNE1 (Hugues A. et al.). Overall, this genetic predisposition to the development of ventricular arrhythmia due to the long QT repolarisation is termed Torsade de Pointes; this is because although clinically the ECG looks similar to that of ventricular tachycardia, in this case the ECG shows a continuously changing QRS vector that is often sparked by the generation of one or two extrasystole occurances(Figure 3...
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Risk factors for Torsade de Pointes include female gender, heart disease, hypokalemia, hypocalcemia, hypomagnesemia, and most importantly drugs that prolong the QT interval. The increase risk in the female gender is believed to due in part to a decrease in repolarisation potential because they produce less repolarising current within the heart (Hugues, A...
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