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The ?32 deletion results in the loss of three of the seven transmembrane domains, two of the three outer loops, and the intracellular signaling domain resulting in a model that looks like figure 4. 8

CCR5?32 is found only in Caucasians of primarily Northern European descent although the deletion has been found all over Europe...

Furthermore, it is believed that selective pressure may have played a role due to the incidence of the bubonic plague or small pox. It is much more likely to link small pox as a contributor since the bubonic plague could not generate sufficient selective pressure to account for current CCR5- 32 frequencies...

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