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Deities to smallpox became a part of the cultures of India, China, and parts of Africa. In Europe, at the end of the 18th century, an estimated 400,000 people died annually from smallpox, and survivors accounted for one-third of all cases of blindness. (http://www.cryptome.org) A method for protection against the naturally acquired smallpox infection appears to have been discovered in India sometime before AD 1000...

There it became the practice to deliberately inoculate, either into the skin or by nasal insufflations, scabs or pustule material from lesions of patients. This practice resulted in an infection that was usually less severe than an infection acquired naturally by inhalation of droplets. Case-Fertility rates associated with variolations, as it was called, were about one-tenth as great as when infection was naturally acquired, but those infected in this manner were capable of transmitting smallpox by droplet inhalation to others...

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