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Topic: Science
Number of pages / Number of words: 5 / 1301
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3).6

Cardiovascular Risk

Since the VIGOR study, several research papers have associated rofecoxib with cardiovascular side effects ? primarily myocardial infarction.1,2,6-10 For example, a study conducted by Hippisley-Cox et al. identified that ?a significantly increased risk of myocardial infarction was associated with current use of rofecoxib' (adjusted odds ratio: 1...


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identified that ?a significantly increased risk of myocardial infarction was associated with current use of rofecoxib' (adjusted odds ratio: 1.32).1

A study published this year by Andersohn et al. has shown that the current use of rofecoxib is also associated with an increased risk of acute ischemic stroke (odds ratio: 1...


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