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Science
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| Number of pages / Number of words: |
16 / 4392 |
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Approximately 11% of Caucasians have intermediate
TPMT activity, and 1 in 300 individuals has a complete
TPMT deficiency. Patients with absent or low TPMT
activity accumulate pharmacologically active thioguanine
nucleotides and develop life-threatening toxic side effects,
mostly pancytopenia attributable to myelosuppression,
under standard therapy [for a review, see Ref...
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(2 )].
Intermediate metabolizers often need a dosage reduction
because of side effects. The molecular bases for many of
the deficient phenotypes are known, and TPMT alleles *1
through *15 have been defined, with *1 referring to the
wild-type allele [see Ref. (3 ) and the references therein].
The most common mutations are TPMT*3A in Caucasians
and TPMT*3C in African and Asian populations (4 )...
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