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| Topic: |
Science
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| Number of pages / Number of words: |
2 / 359 |
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The reaction through which 4-mrthaoxyacetophenone is converted to 4-methoxybenzoic acid is a haloform reaction. This reaction involves two distinct stages that occur in the same environment. The first stage occurs through the based-catalyzed halogenation of the ketone that forms a trihalo ketone. First, the bleach is transformed into chlorine and hydroxide ions through the following reaction:
Then, the hydroxyl is able to attack the rather acidic (pKa ~ 20) ?-hydrogen of the ketone...
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The reaction through which 4-mrthaoxyacetophenone is converted to 4-methoxybenzoic acid is a haloform reaction. This reaction involves two distinct stages that occur in the same environment. The first stage occurs through the based-catalyzed halogenation of the ketone that forms a trihalo ketone. First, the bleach is transformed into chlorine and hydroxide ions through the following reaction:
Then, the hydroxyl is able to attack the rather acidic (pKa ~ 20) ?-hydrogen of the ketone...
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