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| Topic: |
Science
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| Number of pages / Number of words: |
8 / 1968 |
Essay's paper body
AML is subdivided into different subtypes: M0-M7 .
The blood film shows possible acute promyleocytic leukaemia (M3 AML), which is characterised by abnormal hypergranular promyleocytes, acytogenic translocation, and a bleeding disorder secondary to consumptive coagulopathy and fibrynolysis (Bhagavan 2002)
To confirm the diagnosis the lumbar puncture for cerebrospinal fluid examination should be preformed (Hoffbrand 2006) and it may show that the spinal fluid contains leukaemic cells...
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And as for M3 AML it is often positive result.
Cytogenic and molecular analysis should be performed. The cytogenic hallmark for M3 AML consists of a balanced reciprocal translocation between the long arms of chromosomes 15 and 17, designated as t (15; 17). The translocation results in two recombinant chromosomes, one abnormally long 15q+ and one shortened 17q-...
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