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| Topic: |
Science
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| Number of pages / Number of words: |
8 / 2019 |
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Hence by inhibiting IRS-1, PI3K is no longer activated to inhibit GSK-3. Essentially, GSK-3 triggers a negative feedback mechanism that results in its own disinhibition. (FIGURE 2) Novel methods in the treatment of DM type II, involves targeting the signaling pathway of insulin rather than increasing insulin concentrations in a patient...
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Based on GSK 3b association to the Insulin Signaling Pathway, a clear target would be to inhibit either GSK 3a or GSK3b with a small molecule so that disinhibtion will be prevented.
B. Structural Identity
GSK3 is a serine/threonine protein kinase found in two nearly identical isoforms, GSK3a and GSK3b, which are expressed ubiquitously in mammalian tissues...
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