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When more substrate molecules are available they are able to access active sites of enzyme molecules more often. This in turn aids in speeding up the rate of the reaction. However, when concentration reaches a high enough point a problem arises because all enzyme active sites are already engaged. The high concentration of substrate saturates the enzyme and the rate of the reaction is determined by the rate at which the active site converts substrate to product...

When more substrate molecules are available they are able to access active sites of enzyme molecules more often. This in turn aids in speeding up the rate of the reaction. However, when concentration reaches a high enough point a problem arises because all enzyme active sites are already engaged. The high concentration of substrate saturates the enzyme and the rate of the reaction is determined by the rate at which the active site converts substrate to product...

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