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| Topic: |
Science
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| Number of pages / Number of words: |
5 / 1318 |
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This form is 2-4 % of the DS population. The physical features may be milder in these individuals, particularly if there is a large proportion of normal cells.
It was once thought that the unequal chromosome division of mosaic DS takes place early after fertilization, and is a defect in mitotic cell division...
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However, CVS studies have shown that a fetus with 47 (XX or XY) + 21 chromosomes can lose an extra 21 chromosome in some cells, providing an alternate mechanism for the mosaic result. Thus, Mosaic DS may also be related to maternal age. This also means that an increased recurrence risk is theoretically possible, and prenatal studies for subsequent pregnancies would be recommended...
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