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"confirmed multiple wavelet reentry as the cause of AF by multipolar mapping."4 Multiple reentry as the cause of AF was further supported by the demonstration by Kumagai et al. that pathways in certain anatomic locations helped maintain AF.4 More important in AF than anatomic reentry is functional reentry in which "variations in the electrophysiologic properties of contiguous tissues, not anatomic obstacles, may serve as the boundaries" of the circuit...
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For example, "myofilament sliding, the cellular action responsible for muscle contraction, is intimately dependent upon intracellular calcium concentrations" and when the calcium influx is altered so are the function of the myocytes.5 As a result dilation of the atria may occur in several days to weeks...
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