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Topic: Psychology
Number of pages / Number of words: 3 / 687
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Assuming a 2% prevalence of cystic fibrosis in fetuses with echogenic bowel, 20 of 1000 fetuses in our hypothetical cohort will have cystic fibrosis.

There are two major discoveries that have transformed our understanding of cystic fibrosis, a genetic disease in which thick secretions accumulate in airways, digestive organs and sperm duct...


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The first was that cystic fibrosis involves a basic defect in epithelial ion transport, and second which is manifested primarily as the loss of chloride conductance. There are also two major challenges to the chloride channel hypothesis remain. One arises from the structure of the cystic fibrosis gene product, named cystic fibrosis trans membrane conductance regulator (CFTR)...


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