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Sumatriptan is called a selective serotonin agonist because it has a greater affinity for (sticks more to) certain types of serotonin receptors than others.
Other drugs, such as Prozac, Paxil, and Zoloft, are intended for the treatment of depression but they also seem to reduce frequency and/or severity of headaches including migraine (although they are not as effective as sumatriptan against oncoming migraine attacks)...
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These drugs are called selective serotonin reuptake inhibitors, which means they interfere in the reuptake of serotonin back into the interior of the nerve cells (neurons). To understand what reuptake means you need to understand that neurotransmitters, once released, must be quickly grabbed and transported back into the interior of nerve cells for reuse...
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