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Both immigration and emigration can alter allelic frequency. Therefore, a population must be isolated from other populations in order to maintain the frequency of its alleles. If our mouse population lived in a locked warehouse where no other mice could enter or exit, it would be ideal for Hardy-Weinberg equilibrium because there would be no gene flow...
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Gene flow is a genetic exchange due to the migration of fertile individuals or gametes between individuals. If one male mouse expressing the dominant allele for purple fur, if there was such a thing, were to enter the warehouse and mate with several of the females, the gene pool would be altered; evolution would occur...
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