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In chromosomal terms, the cells are trisomic for chromosome 21. Its trisomy severely alters the individual's phenotype. Down syndrome includes characteristic facial features, short stature, heart defects, susceptibility to respiratory infection, and mental retardation. Most cases of Down syndrome result from nondisjunction during gamete production in one of the parents...
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Most cases of Down syndrome result from nondisjunction during gamete production in one of the parents. Nondisjunction, being something in which the members of a pair of homologous chromosomes do not move apart properly during meiosis I, or in which sister chromatids fail to separate during meiosis II...
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