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These plaques are specific to Alzheimer's patients and appear long before the tangles do. The main component of these plaques are peptides made up of 40-42 amino acids, the BAPP protein. However BAPP remains a mystery. Researchers know that many different cells produce BAPP and that it be in between 695-770 amino acids long...
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The protein runs through the outer membrane with a short piece cutting into the cell and a longer piece sticking into the extracellular space. The B-amyloid peptide is cut out of the section of BAPP that spans the cell membrane. Scientists discovered that BAPP is cut in two different ways. One way the proteins is first cleaved by an enzyme called alpha-secretase...
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