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Topic: Science
Number of pages / Number of words: 6 / 1533
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Regardless of which mechanism the anaphylaxis follows, mast cells and basophils are the one initiating and amplifying the acute allergic response (Simons, 2008).

Anaphylaxis is first initiated by the uptake of allergen by professional antigen presenting cells (APCs) which will present selected peptides on MHC class II molecule to naive T cells...

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This will then direct them in favour of a TH¬2- cell phenotype where the transcription factor GATA3 mediates cytokine secretion. This process is known as the “sensitization” stage where the dendritic cells play a crucial role as the professional APCs. Then in the presence of co-stimulation, T-cells coordinately upregulate expression of the genes encoded on human chromosome 5q31-33 where the cytokines will be synthesized...

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