Buy custom Toll like receptors and their therapeutic potential
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Topic: |
Science
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Number of pages / Number of words: |
8 / 2087 |
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They are present in plants, invertebrates and vertebrates, and represent a primitive host defence mechanism against bacteria, fungi and viruses.
There are 13 TLRs that have been discovered in mammals so far, named TLR-1 to TLR-13.
TLRs are primary transmembrane proteins of immune cells, that contain leucine repeats in their extracellular domains and a cytoplasmic tail that contains a conserved region called the Toll / IL1 receptor (TIR) domain...
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This is where the name Toll-like receptor is derived.
Different combinations of TLRs appear in pairs in different cell types. Different TLRs bind directly or indirectly to different microbial molecules.
TLRs found on cell surfaces:
a. TLR-1/TLR-2 pairs bind uniquely bacterial lipopeptides and GPI-anchored proteins in parasites
b...
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General points of the essay
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