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This suggests that syphilis may be a New World mutation of yaws, which has a worldwide distribution (Rose, 1997).
By most historical accounts, it does seem that France was the likely starting point of the European epidemic. During Charles the VIII's Italian campaign in 1495, his mercenaries returned home with this new sickness...
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It spread quickly and viciously. The city of Lyons became so 'contaminated' with diseased people that in March of 1496 the infected people were expelled outside of the city walls. By 1497, the disease had spread throughout France. Less then a decade later, nearly all corners of Europe were already infected as well (Crosby, 1986)...
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