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Topic: Science
Number of pages / Number of words: 13 / 3477
Essay's paper body

Rates and extent of the paracellular transport are, therefore, highly

influenced by the structure and size of the tight junctions as well as by the

size of the molecules. Only small and hydrophilic drugs can pass between the

cells rapidly and completely; permeation of larger molecules can be limited

proportionally to their size and lipophilicity (Hillgren et al...


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1995).

Simple assay methods are needed for drug absorption studies. Excised intestinal

tissue, isolated cells, membrane vesicles and in vivo models have distinct

limitations, which have been previously discussed in detail (Audus et al. 1990;

Artursson 1991; Hillgren et al. 1995). The most suitable method for the study of

drug intestinal transport appeared to be the use of cultured intestinal

epithelial cells...


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