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Topic: Social Issues
Number of pages / Number of words: 9 / 2484
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This modified toxin was suitable for immunizing

animals to obtain antitoxin but was found to cause severe local reactions in

humans and could not be used as a vaccine.

In 1909, Theobald Smith, in the U.S., demonstrated that diphtheria toxin

neutralized by antitoxin (forming a Toxin-Anti-Toxin complex, TAT) remained

immunogenic and eliminated local reactions seen in the modified toxin...


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For some

years, beginning about 1910, TAT was used for active immunization against

diphtheria. TAT had two undesirable characteristics as a vaccine. First, the

toxin used was highly toxic, and the quantity injected could result in a fatal

toxemia unless the toxin was fully neutralized by antitoxin...


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