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Topic: Science
Number of pages / Number of words: 3 / 665
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``Now we understand how all the engine parts operate and we can try to think about ways to make repairs.''

Winer said that this may be only one of the ways women become resistant to tamoxifen.

Tamoxifen is the generic name for AstraZeneca Plc's Nolvadex, no longer made in the U.S., which was developed 30 years ago...


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About 28,000 U.S. women receive tamoxifen as a first- line therapy, according to Cancer Research UK.

The researchers looked at 109 breast cancer tumors, all of which had been treated with tamoxifen. They found that 68 were PAX2-positive and 41 were PAX2-negative. Patients whose tumors were PAX2-positive had a ``significantly improved'' chance of survival without their cancer returning than those whose tumors were PAX2-negative...


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