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Topic: Science
Number of pages / Number of words: 50 / 13866
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By binding fibrinogen or under high shear conditions, von Willebrand factor, conformationally activated GPIIb/IIIa cross-links adjacent platelets, resulting in platelet aggregation.

Damage to the vascular wall and the resultant exposure of tissue factor (TF)-expressing cells to blood initiates coagulation in both the arteries and veins...


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In the presence of calcium, TF binds activated factor VII (factor VIIa), which is found in small amounts in plasma, thereby forming factor VIIa/TF complex. This complex, also known as extrinsic tenase, activates factors IX and X, although factor X activation is more efficient. Factor Xa then converts small amounts of prothrombin to thrombin...


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