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Science
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| Number of pages / Number of words: |
3 / 808 |
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PDGFR-alpha binds each of the three forms of PDGF dimers with high affinity. PDGFR-beta binds both PDGF-BB and PDGF-AB but has no reported binding to PDGF-AA [3,19,20]. PDGF binding activates intracellular tyrosine kinase, leading to autophosphorylation of the cytoplasmic domain of PDGFR, as well as phosphorylation of other intracellular substrates ...
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PDGF binding has been linked to upregulation of ICAM-1 in vascular smooth muscle cells [21], transient induction of T cell IL-2 secretion [22], down-regulation of IL-4 and IFN-gamma production [22] and modulation of thrombospondin expression and secretion [23].
PDGF being a potent mitogen for connective tissue cells, it is implicated in cancer-driven angiogenesis [24]...
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