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Topic: Science
Number of pages / Number of words: 8 / 2204
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This is consistent with the presence of a cAMP-responsive element in the 5'-untranslated region of the AQP2 gene (92, 156) and with the recent demonstration that mice with inherently low cAMP levels have low expression of AQP2 (DI +/+). There was a very slow recovery in AQP2 expression and restoration of urinary concentration after cessation of lithium treatment (149) consistent with clinical findings...


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There was a very slow recovery in AQP2 expression and restoration of urinary concentration after cessation of lithium treatment (149) consistent with clinical findings. However, treatment of lithium-diuretic rats with high doses of the specific V2-receptor agonist dDAVP was able to cause efficient delivery of AQP2 to the apical plasma membrane (a greater fraction of total AQP2 was found in the membrane than seen in control animals), but there was only a modest increase in AQP2 expression relative to animals treated with lithium alone...


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